৳ 300.00

COMPOSITION
Holicef® 250 mg IM Injection: Each vial contains Ceftriaxone Sodium BP eqvt. to Ceftriaxone 250 mg. Each ampoule contains 2 ml Lidocaine Hydrochloride 1% BP.
Holicef® 500 mg IM Injection: Each vial contains Ceftriaxone Sodium BP eqvt. to Ceftriaxone 500 mg. Each ampoule contains 2 ml Lidocaine Hydrochloride 1% BP.
Holicef® 500 mg IV Injection: Each vial contains Ceftriaxone Sodium BP eqvt. to Ceftriaxone 500 mg. Each ampoule contains 5 ml water for injection BP.

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Description

COMPOSITION
Holicef® 1 gm IM Injection: Each vial contains Ceftriaxone Sodium BP eqvt. to Ceftriaxone 1 gm. Each ampoule contains 3.5 ml Lidocaine Hydrochloride 1% BP.
Holicef® 1 gm IV Injection: Each vial contains Ceftriaxone Sodium BP eqvt. to Ceftriaxone 1 gm. Each ampoule contains- 10 ml water for injection BP.
Holicef® 2 gm IV Injection: Each vial contains Ceftriaxone Sodium BP eqvt. to Ceftriaxone 2 gm. Each ampoule contains- 10 ml water for injection BP. (2 ampoule, 20 ml water for injection)
PHARMACOLOGY
Holicef® (Ceftriaxone) is a sterile semi-synthetic broad spectrum 3rd generation Cephalosporin antibiotic for intravenous or intramuscular administration. The bactericidal activity of Ceftriaxone results from inhibition of cell wall synthesis. Ceftriaxone has a high degree of stability in the presence of beta-lactamase, both penicillinases and cephalosporinases of gram-positive and gram-negative bacteria. Holicef® (Ceftriaxone), like other cephalosporins and penicillins, kills bacteria by interfering with the synthesis of the bacterial cell wall. A remarkable feature of Holicef® (Ceftriaxone) is its relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. Ceftriaxone is not metabolized in the body. About 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine; the remainder is excreted in the bile and ultimately found in the faeces as unchanged drug and microbiologically inactive compound. The drug is highly (95%) protein bound.

INDICATIONS
Holicef® is indicated for the treatment of the following infections- 1. Lower respiratory tract infections, particularly pneumonia 2. Renal and urinary tract infections 3. Gonococcal infections 4. Acute bacterial otitis media 5. Skin, soft tissue, bone and joint infections 6. Bacterial meningitis7. Ear, nose and throat infections 8. Typhoid fever 9. Septicemia 10. Infections in cancer patients. 11. Prevention of post-operative infections 12. Pre-operative prophylaxis of infections associated with surgery
DOSAGE & ADMINISTRATION
Adult: By deep intramuscular injection or by intravenous injection over at least 2-4 minutes or by intravenous infusion, 1 gm daily; 2-4 gm daily in severe infections; intramuscular doses over 1 gm divided between more than one site. Neonate: By intravenous infusion over 60 minutes, 20-50 mg/kg daily (max. 50 mg/kg daily). Infant and child under 50 kg: By deep intramuscular injection or by intravenous injection over 2-4 minutes or by intravenous infusion, 20-50 mg/kg daily; up to 80 mg/kg daily in severe infections; doses of 50 mg/kg and over by intravenous infusion only; 50 kg and over, adult dose. Uncomplicated gonorrhea: By deep intramuscular injection, 250 mg as a single dose. Surgical prophylaxis: By deep intramuscular injection or by intravenous injection over at least 2-4 minutes, 1 gm at induction, Preparation of injections and direction for reconstitution of powder : For intramuscular injection : Holicef 250 mg or 500 mg should be dissolved in 2 ml of 1% Lidocaine HCl Injection, Holicef 1 gm in 3.5 ml of 1% Lidocaine HCl Injection. For intravenous injection :Holicef 250 mg or 500 mg should be dissolved in 5 ml of Water for Injection, Holicef 1 gm in 10 ml of Water for Injection, Holicef 2 gm in 20 ml of water for Injection. Use the solution immediately after reconstitution of powder.

SIDE-EFFECTS
GenerallyHolicef® (Ceftriaxone) is well-tolerated. However, few side-effects including- nausea, vomiting, diarrhoea, dizziness and fever may occur.
ADVERSE DRUG REACTIONS
Pain can occur at the site of injection.
Diarrhea occurs in about 3% (children 5-6%).
Convulsion or involuntary movements may occur with ceftriaxone USE.

CONTRAINDICATIONS
Ceftriaxone is contraindicated in patients with known allergy to ceftriaxone, other cephalosporins or penicillins.
USE IN PREGNANCY AND LACTATION
Pregnancy: The safety of Ceftriaxone in the treatment of infection during pregnancy has not been established. Ceftriaxone should only be used during pregnancy if the likely benefit outweighs the potential risk to the fetus or the mother.
Lactation: Ceftriaxone is excreted in breast milk at low concentrations. Therefore, caution should be exercised when Ceftriaxone is administered to a nursing mother.

DRUG INTERACTION
No drug interactions have yet been reported.
OVERDOSAGE
There is no specific antidote. Treatment of overdosage should be symptomatic.

STORAGE
Store below 30°C, Protect from light & moisture. Keep out of the reach of children.
COMMERCIAL PACK
Holicef® 250 mg IM Injection: Each box contains- 1 combipac (1 vial of 250 mg Ceftriaxone with1 ampoule of 2 ml Lidocaine HCl 1% injection), Sterile disposable syringe 5 ml, Alcohol pad, First aid bandage & Baby needle.
Holicef® 500 mg IM Injection: Each box contains- 1 combipac (1 vial of 500 mg Ceftriaxone with 1 ampoule of 2 ml Lidocaine HCl 1% injection), Sterile disposable syringe 5 ml, Alcohol pad, First aid bandage.
Holicef® 500 mg IV Injection: Each box contains- 1 combipac (1vial of 500 mg Ceftriaxone with 1 ampoule of 5 ml water for injection), Sterile disposable syringe 5 ml, Alcohol pad, First aid bandage & 1 vein set.
Holicef® 1 gm IM Injection: Each box contains- 1 combipac (1 vial of 1 gm Ceftriaxone with 1 ampoule of 3.5 ml Lidocaine HCl 1% injection), Sterile disposable syringe 5 ml, Alcohol pad, First aid bandage.
Holicef® 1 gm IV Injection: Each box contains- 1 combipac (1vial of 1 gm Ceftriaxone with 1 ampoule of 10 ml water for injection), Sterile disposable syringe 10 ml, Alcohol pad, First aid bandage & 1 vein set.
Holicef® 2 gm IV Injection: Each box contains- 1 combipac (1vial of 2 gm Ceftriaxone with 2 ampoules of 10 ml water for injection), Sterile disposable syringe 20 ml, Alcohol pad, First aid bandage & 1 vein set.

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